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by Dr Brendan
Last updated: January 2009
Recent decades have seen the
accumulation of substantial evidence to support the idea that
disturbances to the development of the brain and nervous system
during gestation increase the risk of schizophrenia: this is
the ‘neurodevelopmental theory of schizophrenia’ (Murray et al, 1992; Weinberger, 1996).
Multiple lines of evidence have been developed
to support this theory, including studies based on evidence of
disturbed craniofacial development, neurological soft signs,
dermatoglyphic anomalies, and other indices of prenatal
disturbances to neural development.
This module aims to explore these specific
lines of evidence and to examine how they might be integrated into
a ‘life-course’ approach to the aetiology of schizophrenia.
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