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Section 1: Antipsychotic drugs and the dopamine hypothesis

(1.1) Section 1: Antipsychotic drugs and the dopamine hypothesis

(1.2) The main classes of antipsychotic drugs

(1.3) Pharmacological effects of the second-generation antipsychotic drugs

(1.4) The subclassification of antipsychotic drugs

(1.5) The dopamine hypothesis of schizophrenia

(1.6) The dopamine hypothesis – current evidence from imaging studies

(1.7) Can we be sure dopamine D2 receptors are important in antipsychotic action?

(1.8) PET evidence implicates dopamine D2 receptors as important in antipsychotic action

(1.9) Function of dopamine pathways in the brain

(1.10) The neuropsychological basis for the antipsychotic effect of dopamine D2 receptor antagonism

(1.11) Section 1: Recap

(1.12) Section 1: Summary

 

Section 2: Pharmacological mechanisms differentiating antipsychotic drugs

(2.1) Section 2: Pharmacological mechanisms differentiating antipsychotic drugs

(2.2) What underlies the 'atypicality' of second-generation antipsychotic drugs?

(2.3) Reflection: suggested answer

(2.4) Pharmacological mechanisms of reduced EPS in antipsychotic drugs

(2.5) Aripiprazole is unique as a partial agonist at dopamine D2 receptors

(2.6) The pharmacology of clozapine's antipsychotic action

(2.7) Section 2: Recap

(2.8) Section 2: Summary

 

Section 3: Neurochemistry and pharmacology of the limitations of antipsychotic drug action

(3.1) Section 3: Neurochemistry and pharmacology of the limitations of antipsychotic drug action

(3.2) Introduction

(3.3) The neurotransmitter basis of symptoms in schizophrenia

(3.4) The neurotransmitter basis of symptom response to antipsychotic drugs

(3.5) The neurotransmitter pathology of schizophrenia

(3.6) Cognitive symptoms and antipsychotic drug treatment

(3.7) Negative symptoms and antipsychotic drug treatment

(3.8) Depression and antipsychotic drug treatment

(3.9) Receptor mechanisms of the antidepressant effect of antipsychotic drug treatment

(3.10) The anti-manic mechanism of antipsychotic drugs

(3.11) Section 3: Recap

(3.12) Section 3: Summary

 

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