Module introduction

By the end of this module, we hope you will be able to:

 

  • understand both the importance and limitations of the dopamine hypothesis of schizophrenia, and its relevance to antipsychotic action

 

  • identify the primary pharmacological effects of different classes of antipsychotic drugs and the mechanisms underlying the differences between them

 

  • assess the evidence for the central role of dopamine D2 receptor antagonism in the relief of positive symptoms

 

  • understand that dopamine hyperfunction is secondary to abnormalities in GABA and/or glutamate neurons, which may in turn relate to cognitive and negative symptoms

 

  • understand the limitations of D2 antagonism in the response of these symptoms, and some of these symptoms being influenced by the possible role of 5-HT receptor mechanisms.

 

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